GrassTFDB :: Browse Family::Sorghum

Displaying GRF Family from Sorghum


Previously, we identified a novel rice gene, GROWTH-REGULATING FACTOR1 (OsGRF1), which encodes a putative transcription factor that appears to play a regulatory role in stem elongation. We now describe the GRF gene family of Arabidopsis thaliana (AtGRF), which comprises nine members. The deduced AtGRF proteins contain the same characteristic regions--the QLQ (Gln, Leu, Gln) and WRC (Trp, Arg, Cys) domains--as do OsGRF1 and related proteins in rice, as well as features indicating a function in transcriptional regulation. Most of the AtGRF genes are strongly expressed in actively growing and developing tissues, such as shoot tips, flower buds, and roots, but weakly in mature stem and leaf tissues. Overexpression of AtGRF1 and AtGRF2 resulted in larger leaves and cotyledons, as well as in delayed bolting of the inflorescence stem when compared to wild-type plants. In contrast, triple insertional null mutants of AtGRF1-AtGRF3 had smaller leaves and cotyledons, whereas single mutants displayed no changes in phenotype and double mutants displayed only minor ones. The alteration of leaf growth in overexpressors and triple mutants was based on an increase or decrease in cell size, respectively. These results indicate that AtGRF proteins play a role in the regulation of cell expansion in leaf and cotyledon tissues.

Protein Name
accepted / suggested
Gene Locus Synonym/
Gene Name
Clone in TFome Genome Browser
SbGRF1 Sb01g009330 View in Browser
SbGRF2 Sb01g012170 View in Browser
SbGRF3 Sb02g032860 View in Browser
SbGRF4 Sb04g030770 View in Browser
SbGRF5 Sb04g031890 View in Browser
SbGRF6 Sb04g034800 View in Browser
SbGRF7 Sb05g021480 View in Browser
SbGRF8 Sb06g027465 View in Browser
SbGRF9 Sb10g001350 View in Browser
SbGRF10 Sb10g006690 View in Browser