GrassTFDB :: Browse Family::Sugarcane


Displaying bHLH Family from Sugarcane


INFORMATION ABOUT bHLH FAMILY

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that bind as dimers to specific DNA target sites and that have been wellcharacterized in nonplant eukaryotes as important regulatory components in diverse biological processes. Based on evidence that the bHLH protein PIF3 is a direct phytochrome reaction partner in the photoreceptor signaling network we have undertaken a comprehensive computational analysis of the Arabidopsis genome sequence databases to define the scope and features of the bHLH family. Using a set of criteria derived from a previously defined consensus motif we identified 147 bHLH protein-encoding genes making this one of the largest transcription factor families in Arabidopsis. Phylogenetic analysis of the bHLH domain sequences permits classification of these genes into 21 subfamilies. The evolutionary and potential functional relationships implied by this analysis are supported by other criteria including the chromosomal distribution of these genes relative to duplicated genome segments the conservation of variant exon/intron structural patterns and the predicted DNA binding activities within subfamilies. Considerable diversity in DNA binding site specificity among family members is predicted and marked divergence in protein sequence outside of the conserved bHLH domain is observed. Together with the established propensity of bHLH factors to engage in varying degrees of homodimerization and heterodimerization these observations suggest that the Arabidopsis bHLH proteins have the potential to participate in an extensive set of combinatorial interactions endowing them with the capacity to be involved in the regulation of a multiplicity of transcriptional programs. We provide evidence from yeast two-hybrid and in vitro binding assays that two related phytochrome-interacting members in the Arabidopsis family PIF3 and PIF4 can form both homodimers and heterodimers and that all three dimeric configurations can bind specifically to the G-box DNA sequence motif CACGTG. These data are consistent in principle with the operation of this combinatorial mechanism in Arabidopsis.


Protein Name
accepted / suggested
Gene Locus Synonym/
Gene Name
Clone in TFome Genome Browser
ScbHLH1 SCBFAD1046D01.g View in Browser
ScbHLH2 SCCCLR1022C05.g View in Browser
ScbHLH3 SCCCLR1068E05.g View in Browser
ScbHLH4 SCCCLR1076F07.g View in Browser
ScbHLH5 SCCCRT1003E06.g View in Browser
ScbHLH6 SCCCRT1C05E01.g View in Browser
ScbHLH7 SCCCRZ1001H05.g View in Browser
ScbHLH8 SCCCRZ2001E12.g View in Browser
ScbHLH9 SCEPRT2043C06.g View in Browser
ScbHLH10 SCEZHR1083B10.g View in Browser
ScbHLH11 SCEZRT2019C07.g View in Browser
ScbHLH12 SCEZRZ1015E08.g View in Browser
ScbHLH13 SCJLRT1021A10.g View in Browser
ScbHLH15 SCMCCL6050E05.g View in Browser
ScbHLH16 SCQSAM1031B04.g View in Browser
ScbHLH17 SCQSFL1127E12.g View in Browser
ScbHLH19 SCQSLB1052C08.g View in Browser
ScbHLH20 SCQSRT1035F04.g View in Browser
ScbHLH21 SCRFLR1012A11.g View in Browser
ScbHLH22 SCRULB1059A08.g View in Browser
ScbHLH23 SCSFRT2070A07.g View in Browser
ScbHLH24 SCUTLR2030B08.g View in Browser
ScbHLH25 SCVPFL1136G10.g View in Browser
ScbHLH26 SCVPRT2074E11.g View in Browser
ScbHLH27 PTSo01104.1 View in Browser
ScbHLH29 PTSo01098.1 View in Browser
ScbHLH30 PTSo01128.1 View in Browser
ScbHLH31 PTSo01095.1 View in Browser
ScbHLH32 PTSo01094.1 View in Browser
ScbHLH33 PTSo01108.1 View in Browser
ScbHLH34 PTSo01099.1 View in Browser
ScbHLH35 PTSo01106.1 View in Browser
ScbHLH36 PTSo01088.1 View in Browser
ScbHLH37 PTSo01091.1 View in Browser
ScbHLH38 PTSo01107.1 View in Browser
ScbHLH39 PTSo01110.1 View in Browser
ScbHLH40 PTSo01103.1 View in Browser
ScbHLH41 PTSo01087.1 View in Browser
ScbHLH42 PTSo01096.1 View in Browser
ScbHLH43 SCQSST3116B02.g View in Browser
ScbHLH49 SCQSRT3052A11.g View in Browser
ScbHLH54 SCSFFL8044H04.g View in Browser
ScbHLH55 SCSFRT2071B03.g View in Browser
ScbHLH57 SCQSRT2034E01.g View in Browser
ScbHLH60 SCCCLR2003D10.g View in Browser
ScbHLH65 SCSGAM2076A07.g View in Browser
ScbHLH66 SCAGAD1076G06.g View in Browser
ScbHLH67 SCEZAM2035A03.g View in Browser
ScbHLH69 SCEZRT2020F12.g View in Browser
ScbHLH70 SCEQRT2026E03.g View in Browser
ScbHLH72 SCCCFL4095H11.g View in Browser
ScbHLH74 SCCCFL5003B01.g View in Browser
ScbHLH75 SCCCCL3001F12.b View in Browser
ScbHLH76 SCQSLB1049E03.g View in Browser
ScbHLH78 SCSGAM2102F05.g View in Browser
ScbHLH81 SCVPST1060E04.g View in Browser
ScbHLH84 SCEPAM2013E03.g View in Browser
ScbHLH85 SCSGRT2066E06.g View in Browser
ScbHLH86 SCSBAD1053E03.g View in Browser
ScbHLH88 SCRLAM1009H06.g View in Browser
ScbHLH89 SCBGFL4053B04.g View in Browser
ScbHLH90 SCEZRZ3017D07.g View in Browser
ScbHLH91 SCJLST1023C02.g View in Browser